Effect of Centella Asiatica Extract
1.anti-inflammation, anti-sensitivity and relief of inflammation is one of the important mechanisms of skin sensitivity, and inhibition of inflammation is an important way of anti-sensitivity and relief of skin. Some people conducted a control experiment between Asiaticosides and dexamethasone. The experimental methods included the rat cotton ball granuloma experiment and the xylene induced ear swelling experiment in mice. The results showed that Asiaticosides had obvious anti-inflammatory effect, and the intensity was equivalent to that of dexamethasone. Another experiment showed that the inhibition rate of Centella asiatica extract on hyaluronidase was very obvious, reaching 96.94%, which was higher than the inhibition rate of dipotassium glycyrrhizinate as a positive control, indicating that Centella asiatica extract had a significant effect on anti-sensitization. In addition, Centella asiatica also contains a variety of A-aromatic resin alcohol type triterpene components, which has a sedative and stable effect. Adding it to skin care products can help calm the skin and relieve sensitivity.
2. The extract of Centella asiatica can promote the synthesis of collagen Ⅰ and Ⅲ, as well as the secretion of mucopolysaccharide (such as the synthesis of hyaluronic acid), increase the water retention of the skin, activate and renew skin cells, make the skin shiny and moist, keep the skin elastic and firm, smooth the small wrinkles of the face, and delay the skin aging.
3.The mechanism of promoting wound healing is mainly as follows: (1) promoting the proliferation, differentiation and chemotaxis of skin keratinocytes to accelerate wound healing. (2) In the early stage of wound, it can promote collagen synthesis and angiogenesis, stimulate granulation growth, and facilitate wound healing. (3) In the early stage of wound, it induces significant increases in the levels of antioxidants such as superoxide dismutase, glutathione, catalase, vitamin C, and vitamin E in the local wound, and reduces the level of lipid peroxide in the wound, thereby reducing the local cell damage of wound, reducing the degree of wound, and promoting wound healing.
4. The mechanism of inhibiting scar hyperplasia is mainly as follows: (1) Asiaticoside has been used to treat keloid fibroblasts cultured in vitro, and it is found that asiaticoside can inhibit the proliferation of keloid fibroblasts and reduce the expression level of connective tissue growth factor. (2) Keloid is a chronic inflammatory reaction, and the content of HIF-1α, IL-6, IL-8 and other pro-inflammatory factors in scar tissue increases. The inflammatory reaction caused by this will lead to abnormal differentiation and excessive proliferation of cells, further aggravate scar and form a vicious circle. The good anti-inflammatory effect of Centella asiaticoides extract is also one of the mechanisms of its prevention and treatment of scar hyperplasia. (3) Some network pharmacology research methods believe that Centella asiatica can improve the inflammatory response, hypoxia state and proliferation balance of fibroblasts in scar patients by regulating TNF signaling pathway, MAPK signaling pathway and HIF-1 signaling pathway, which has the characteristics of multi-center, multi-target and multi-pathway effects. Maquart et al. used Centella asiatica to treat burn scar symptoms, and the results showed that the skin pain and itching were significantly relieved after 3-5 days of using the drug.
5, Centella asiatica extract has a certain whitening and acne. The main mechanism of its whitening effect is as follows: (1) it inhibits tyrosinase activity and reduces melanin formation; (2) reduce inflammatory hyperpigmentation by anti-inflammatory effect. The main mechanism of its anti-acne effect is as follows: (1) inhibition of Propionibacterium acnes; (2) reduce the degree of skin lesions and pigmented acne marks by anti-inflammatory effect; (3) Prevention and treatment of pockmarks by promoting wound healing and inhibiting scar hyperplasia.
The Taboo of Centella Asiatica
Jixuecao cold, so there will be some food contraindications. First of all, people with cold constitution are not suitable for eating centella asiatica. At the same time, female friends can not eat centella asiatica during menstruation. Cold constitution generally feels cold hands and feet, so before eating any traditional Chinese medicine, you need to understand your own constitution, and take the corresponding traditional Chinese medicine that meets your own health needs, which is also a kind of responsibility for your own health!
In addition, the side effects of centella asiaticosa also depend on the size of the drinking amount, the medicinal materials are not ordinary food, and the dosage and usage have obvious restrictions. Once centella asiaticosa is consumed in excess, the user may feel dizzy, which is obviously more than worth it. More serious, excessive consumption of centella asiatica may also lead to patients with coagulopathy and other toxic symptoms, encounter this situation should not be careless, must stop eating in time, consult a doctor or relevant experts.
As a kind of traditional Chinese medicine with various curative effects, Jixuecao is indeed very popular among patients. At the same time, many friends who pay attention to health will also use Jixuecao to cook many dishes to achieve the role of food therapy and health.