What Is Hesperidin?
Hesperidin is a flavonoid glycoside that occurs naturally in a variety of fruits, particularly citrus fruits. Its chemical structure comprises a flavanone backbone and a sugar molecule, often glucose. As a glycoside, hesperidin is typically bound to a sugar molecule, which means it must be broken down during digestion to become bioavailable in the body. This process enables hesperidin to be absorbed and utilized for its antioxidant and anti-inflammatory effects.
Flavonoids like hesperidin have garnered attention for their health-promoting properties. In the body, hesperidin functions as an antioxidant, neutralizing free radicals that can cause cellular damage and contribute to aging and chronic diseases. Beyond its antioxidant properties, hesperidin is believed to influence several physiological processes, including blood circulation, inflammation, and even weight management.
What Foods Are Highest in Hesperidin?
Citrus fruits are the most abundant natural source of hesperidin. Oranges, grapefruits, lemons, and tangerines are particularly rich in this flavonoid. The white pith that lies beneath the peel of citrus fruits contains the highest concentration of hesperidin, though it can also be found in the juice and flesh of the fruit. The content of hesperidin in these fruits can vary depending on the variety and ripeness of the fruit.
Other fruits and plants that contain hesperidin, though in smaller amounts, include:
- Lemon peel: Offers a rich source of flavonoids, including hesperidin.
- Citrus peels: While often discarded, citrus peels are full of flavonoids, including hesperidin.
- Bitter oranges: These are known for their high hesperidin content and are often used in traditional medicine.
For those who are looking to increase their intake of hesperidin, it’s often easier to incorporate citrus fruits into the diet. Citrus juices, peels, and extracts are some of the most convenient options, although supplements containing hesperidin are also available for those who may not consume enough citrus fruits.
What Are the Benefits of Hesperidin?
Cardiovascular Health
One of the most prominent benefits of hesperidin is its ability to improve cardiovascular health. Research has shown that hesperidin may help reduce blood pressure, improve circulation, and reduce the risk of atherosclerosis, a condition characterized by the buildup of plaque in the arteries. Hesperidin achieves these effects by enhancing the endothelial function, which refers to the ability of the blood vessels to relax and contract as needed to maintain healthy blood flow. It is believed to strengthen the blood vessel walls, helping prevent conditions like high blood pressure and the narrowing of arteries.
Some studies have also suggested that hesperidin can reduce oxidative stress in the cardiovascular system, which helps protect the blood vessels and heart from damage. This antioxidant property, combined with its ability to improve blood circulation, makes hesperidin an excellent choice for maintaining a healthy heart.
Anti-Inflammatory Properties
Inflammation is a natural immune response, but chronic inflammation can contribute to a variety of health problems, including arthritis, heart disease, and cancer. Hesperidin has been found to possess potent anti-inflammatory properties, which may help manage and prevent these chronic conditions. Research has shown that hesperidin can modulate the inflammatory pathways in the body, inhibiting the production of inflammatory cytokines and enzymes like COX-2. By reducing inflammation at the cellular level, hesperidin can help mitigate pain and swelling associated with inflammatory diseases.
Antioxidant Effects
Hesperidin is a powerful antioxidant, meaning it helps neutralize free radicals in the body. Free radicals are unstable molecules that can damage cells, proteins, and DNA, leading to aging and the development of diseases such as cancer, Alzheimer’s, and cardiovascular conditions. By neutralizing these free radicals, hesperidin can reduce oxidative stress and prevent cellular damage. This antioxidant activity is particularly valuable in aging and degenerative diseases, where oxidative stress plays a central role in disease progression.
Skin Health
The skin, as the largest organ in the human body, is particularly vulnerable to oxidative damage caused by free radicals and environmental factors like UV radiation. Hesperidin’s antioxidant properties make it a valuable ingredient in skin health. Studies suggest that hesperidin can improve skin hydration, elasticity, and tone by protecting skin cells from oxidative stress and promoting healthy blood circulation. Additionally, its anti-inflammatory properties can help reduce skin irritation and redness, making it a popular ingredient in skincare products designed to soothe sensitive or inflamed skin.
Weight Management
Some research has suggested that hesperidin may help in weight management by influencing fat metabolism and energy expenditure. A study conducted on obese mice found that hesperidin supplementation resulted in reduced fat accumulation and improved metabolic markers. Although more research is needed to confirm the exact mechanism by which hesperidin affects weight loss in humans, its antioxidant and anti-inflammatory effects may play a role in reducing the risk of obesity-related diseases.
How Much Hesperidin Should You Take Per Day?
The optimal daily intake of hesperidin has not been definitively established, but studies suggest that dosages of 500–1000 mg per day are generally well tolerated. This amount is usually derived from citrus fruit or hesperidin supplements. The exact dosage will vary depending on factors such as age, health condition, and individual response to the compound.
For general health benefits, consuming one to two servings of citrus fruits per day should provide a beneficial dose of hesperidin. For those who prefer supplements, many products offer hesperidin in capsule or powder form. However, it's important to consult a healthcare provider before taking hesperidin supplements, especially for individuals with pre-existing conditions or those on medications, as interactions may occur.
Hesperidin Supplier - Contact SOST Biotech
For those looking to source high-quality hesperidin for personal use or commercial applications, SOST Biotech is a reliable supplier. We offer pure hesperidin extracts that are derived from premium citrus fruits and undergo rigorous testing to ensure purity and potency. Whether you're a manufacturer looking to formulate new products or a health-conscious individual seeking the benefits of this powerful flavonoid, SOST Biotech provides top-notch hesperidin in various forms to suit your needs.
Contact SOST Biotech today for more information on our products and services.
References
- Patel, D., & Soni, M. (2015). Hesperidin: A Review on the Pharmacological Effects. International Journal of Pharmaceutical Sciences Review and Research, 35(1), 6–11.
- Puglisi, M., & D'Antuono, L. F. (2018). Citrus Bioflavonoids and Their Role in Cardiovascular Health. Molecules, 23(10), 2468.
- Costa, L. G., et al. (2020). Antioxidant Properties of Hesperidin and Its Effects on Human Health. Antioxidants, 9(11), 1145.
- Lee, S., & Lee, H. (2019). Skin Benefits of Flavonoids: An Overview of Hesperidin. Journal of Dermatological Science, 95(1), 4–10.