1.What is D-Alpha tocopherol succinate?
α-Tocopherol succinate (α-TOS) is an esterified derivative of α-Tocopherol (α-TOH), the main component of vitamin E. It has the anti-aging effects of vitamin E (vitamin E is a positive control for many anti-aging efficacy evaluations), antioxidant effects, and avoids the disadvantages of vitamin E instability (easy to change color).
Tocopherol succinate has good photostability and high temperature resistance. No degradation reaction occurred after 1 week of UV irradiation and 6 months of natural light irradiation, and no degradation reaction occurred within 24 hours at 100℃.
2.D-Alpha tocopherol succinate benefits
Compared with tocopherol, tocopherol succinate (TOS) is chemically more stable due to its protected phenolic hydroxyl group from oxidation. In addition, the surface activity of TOS is improved by the introduction of hydrophilic carboxyl groups. In addition to its antioxidant properties, it can also play a role in moisturizing, whitening and other functions, thus expanding its application field.
(1) Antioxidant
α-tocopherol is a potent lipophilic cleavage antioxidant and acts as an inhibitor of lipid peroxidation. In mice, vitamin E treatment reduced levels of markers of oxidative stress, and long-term supplementation delayed cognitive impairment, preserved markers of cholinergic cell survival, and maintained hippocampal morphology.As an ingredient in skin care products, it has anti-inflammatory and anti-proliferative effects in concentrations between 2% and 20%. It smoothes the skin, increases the ability of the stratum corneum to retain moisture and helps resist skin photoaging.
Meanwhile, α-tocopherol is also the main form of vitamin E in human tissues and contributes to the skin's antioxidant defense system by protecting cell membranes from lipid peroxidation.
(2) Anti-aging
In the process of metabolism, our body forms a variety of free radicals. Of these, 95% are oxygen free radicals, which are bad for us. They attack cells, produce oxidation, damage cell function, and reduce the vitality of the human body. On the other hand, the body's own antioxidant capacity decreases with age. With the increase of age, the production of oxygen free radicals gradually exceeds the body's ability to withstand, and the characteristics of aging begin to occur.
As the active ingredient of cosmetics, tocopherol succinate has a small molecular weight, which can penetrate the skin, efficiently remove free radicals, maintain the balance of free radicals, promote collagen regeneration, promote metabolism, make the skin smooth, delicate and elastic, improve skin lines, and have the effect of delaying aging.
Studies have shown that higher vitamin E content is associated with better anti-aging effects.
(3) Whitening and light spots
Melanin tends to cause discoloration, which is caused by the deposition of melanin on the surface of the skin. The reason why melanin can be synthesized is that tyrosinase catalyzes tyrosine, which is then converted to quinba and finally transported to the epidermis to cause melanin accumulation.
Vitamin E has been shown to effectively restore the function of endogenous antioxidant enzymes to normal levels, which can effectively inhibit the activity of tyrosinase, so that tyrosine can not be used, thereby reducing the production of melanin.
The gel formulation loaded with tocopherol succinate was proved to be highly thermostable over 3 months. Redness and swelling, melanin and sebaceous levels were decreased, and water content and elasticity were improved (p< 0.05).
(4) Improve skin wrinkles, laxity, and dark yellow
In anti-aging skin care products, vitamin E has obvious effects on skin wrinkles, laxity, dark yellow, etc.
The scientists found that 20 volunteers were tested for the anti-aging efficacy of a cosmetic formula containing vitamin E, palmityl peptide, and silymarin seed oil. Experiments have confirmed that vitamin E-containing complexes have improved effects on wrinkles, decreased elasticity, and yellowing of skin caused by aging (in fact, this cannot be explained by vitamin E alone, but can only be said to have a strong assist effect).
3.Our Strengths
The D-Alpha tocopherol succinate developed by SOST BIOTECH is prepared by enzymatic catalysis under mild reaction conditions. Biological enzymes can be degraded, more environmentally friendly; High specificity and few by-products; The activity can be regulated; Effectively avoid the use of strong acid, alkali or other metal catalysts; Avoid residue of harmful substances.
Tocopherol succinate, whose phenolic hydroxyl group is protected, resulting in increased chemical stability. In addition, the surface activity of tocopherol succinate is improved by introducing a hydrophilic carboxyl group into the molecule. In addition to its antioxidant properties, tocopherol succinate can also play a role in skin moisturizing and moisturizing.
If you are looking for suppliers of D-Alpha tocopherol succinate acid powder, please contact us~
Email:ericyang@xasost.com
REFERENCE
Ganceviciene R, Liakou A I, Theodoridis A, et al. Skin anti-aging strategies[J]. Dermato-endocrinology, 2012, 4(3): 308-319.
Zhai H, Behnam S, Villarama C D, et al. Evaluation of the antioxidant capacity and preventive effects of a topical emulsion and its vehicle control on the skin response to UV exposure[J]. Skin pharmacology and physiology, 2005, 18(6): 288-293.
Chu C C, Chew S C, Liew W C, et al. Review article vitamin E: a multi-functional ingredient for health enhancement and food preservation[J]. Journal of Food Measurement and Characterization, 2023, 17(6): 6144-6156.
Q. Jiang, S. Im, J.G. Wagner, M.L. Hernandez, D.B. Peden, Gamma-tocopherol, a major form of vitamin E in diets: insights into antioxidant and anti-inflammatory effects, mechanisms, and roles in disease management. Free Radic. Biol. Med. 178, 347– 359 (2022).