What is resveratrol extracted from?
Resveratrol, chemically known as 3, 4', 5-trihydroxystilbene, is a non-flavonoid polyphenolic compound, which is a phytodefense element produced by plants (mainly seed plants) when encountering unfavorable conditions such as fungal infections and ultraviolet irradiation, and plays a protective role for the plants themselves. Resveratrol and its derivatives are mainly found in at least 72 species of plants from 21 families and 31 genera, including grape, polygonum, peanut and quinoa, including common medicinal plants such as tiger nuts, cassia and mulberry, as well as crops such as grapes and peanuts. At present, the main sources of natural resveratrol are tiger nuts and grapes.
Polygonum cuspidatum belongs to the Polygonaceae family, is a perennial shrubby herb, mainly distributed in China's provinces south of the Yangtze River and Hubei, Sichuan and other places. The roots and rhizomes of Polygonum cuspidatum are the main parts for the extraction of natural resveratrol, which mainly exists in Polygonum cuspidatum plants in the form of silymarin, and the content of resveratrol is very small in plants, and a high content of resveratrol can be obtained by the method of bio-enzymes. Among them, the content of resveratrol in the fresh root is higher than that in the fresh stem, and the fresh leaves contain almost no resveratrol.
Grapes are deciduous vine plants of the genus Vitis, family Vitaceae, and are planted all over the north of the Yangtze River Basin in China. The content of resveratrol in wild and artificially cultivated spiny grapes (Vitis davidii Foex) in Hunan and Guizhou is relatively high. The content of resveratrol in grapes varies according to varieties, and the content varies in different parts. Resveratrol in grapes is mainly found in the vines, skins and seeds, with little or no resveratrol in the pulp. Each gram of fresh grape skin contains about 50~100μg, and the concentration in red wine is as high as 1.5~30mg/ L. The concentration of resveratrol in red wine is about 1.5~30mg/ L.
Chemically synthesized resveratrol：The synthesis of resveratrol by microbial fermentation has the advantages of being more green and environmentally friendly. It was found that the synthesis of resveratrol requires L-tyrosine or L phenylalanine as A precursor, which is generated by binding 3 molecules of malonyl-coa. The de novo synthesis of resveratrol has been achieved by expressing the plant-based resveratrol synthesis pathway in microbial hosts, but the yield is low, which is difficult for industrial production. In addition, modern studies have shown that resveratrol is a very important food additive and preventive medicine, which has good effects on inflammation, cardiovascular disease, and anti-fatigue.
Legal Recognition
Natural resveratrol has cis and trans structures, they can be combined with glucose to form cis and trans resveratrol glycosides respectively, glycosides of which can release resveratrol under the action of glycosidases in the intestines. In terms of activity embodiment, monomer is superior to glycoside, and trans is superior to cis, so the products on the market are mostly trans-resveratrol.
China Chamber of Commerce for Import and Export of Medicines and Health Products (CCCMHPIE) issued T/CCCMHPIE 1.7-2016 Plant Extracts Tiger Balm Extracts standard clearly states that resveratrol in the extracts should be ≥50%. Currently, resveratrol has been allowed to be used in dietary supplements in the United States. The European Union is also continuing to relax the conditions of access to trans-resveratrol. in November 2012, DSM Nutritional Products Ltd, a leading trans-resveratrol company, applied to the Irish authorities for the inclusion of trans-resveratrol as a new food ingredient. in June 2013, the competent food assessment authority in Ireland issued a preliminary assessment report.
In the report, it was concluded that trans-resveratrol meets the criteria for a novel food ingredient as set out in Article 3(1) of Regulation (EC) No 258/97.In July 2016, the European Union issued Commission Implementing Decision (EU) 2016/1190 authorizing trans-resveratrol as a novel food ingredient, which can be marketed in the form of capsules or tablets.In January 2021, the European Union revised the definition of trans-resveratrol as a novel food ingredient in accordance with the application. conditions of use and labeling requirements for resveratrol as a novel food, removing the dosage form restrictions. This regulation is a great impetus to expand the application of resveratrol in the EU market.
Market Application and Product Dynamics
According to public data, in the past two years, there have been nearly 1,000 types of resveratrol medicines and healthcare products approved and listed in the European and American markets, with about 200 million users globally, while growing at an average rate of 50 million people per year. According to the latest market analysis report, the production of resveratrol industry in 2021 was 19.0 tons and the sales volume reached 18.6 tons. Resveratrol industry profit is expected to reach $39.08 million by 2027. Moreover, the global resveratrol market size is expected to reach $147 million by 2030, at a CAGR of 6.83%. The research found that dietary supplements is one of the most widely used applications of resveratrol, in which the beverage industry is more willing to embrace resveratrol than the food industry in newly launched food and beverage products, especially functional beverages. In addition, consumer preference for natural products will also drive the widespread use of resveratrol in supplements.
In the health care industry, in 2010, a U.S. company launched the first resveratrol-enriched anti-aging drink, which was called “the world's most functional drink”. In recent years, some resveratrol products have also appeared in China, such as some capsule products. In terms of medicine, domestic resveratrol as a drug listing has not yet been reported, while foreign patented drugs are very representative. Some researchers have applied for patents on the use of resveratrol as a component of cancer chemopreventive agents and its application methods. There is also a patent for the use of trans-resveratrol for the treatment of high blood cholesterol, which reduces the risk of excessive blood cholesterol by taking 50 to 1,000 mg of trans-resveratrol on a daily basis in the form of pills, capsules or transdermal patches. In conclusion, resveratrol has great potential for drug development. Now in Europe and the United States has been approved for marketing resveratrol high-end preparations (including drugs and health care products) has reached more than 1,000 kinds of products, and its products are used by more than 200 million people around the world. It is estimated that the sale of resveratrol preparations will form a huge industry in the future, and its market prospect is very favorable.
Conclusion
Resveratrol, as a variety of bioactive natural polyphenolic plant extracts, has great potential for application and broad market prospects, both in the cosmetic field and in the food field.If you need to procure resveratrol powder, please contact sost Biotech~